I am sympathetic towards Takeshi Shudo. Tyrannosaurus rex was and is (also when you consider Tyrantrum) way more menacing than anything Entei or Unown could have produced. Despite its first appearance in the anime being intertwined with prehistoric Pokémon, there actually could have had a Charizard vs Tyrannosaurus Rex fight exist...
For an animal that wouldn't be a Pokémon to have logically be capable to coexist in tamed harmony via Pokémon training does counter against Takeshi's story of an alternate evolutionary theory to Darwin's evolution by natural selection, something that generally seen oppositely towards Pokemon's more strategic basis concerning growth and maturity. In an ideal solution the former form of evolution in topic was most likely to be a plothole for Prof. Oak to have researched upon about how these creatures lived and died the way they are.
I find his influence as to how this idea came about indeed fascinating. Knowing how much Pokémon has seemed taken fancy the resurrection of fossils as a main core since the beginning really surprises me how much they have referred from my understanding to similar concepts found in the Jurassic Park franchise. Surely Shudou Takeshi undoubtedly must had been inspired by it at the time, let alone Satoshi Tajiri with his naturalist interest of collecting insects. For me, even when I first read the Mewtwo pokedex entry on the games and Base set holo (10/102) before the first movie came out, "A scientist created this Pokémon after years of horrific gene-splicing and DNA engineering experiments.", it immediately made me think of the science behind Jurassic Park's creation of gene modification. Even now, Jurassic World seems to have made this origin seem imminent when it decided to make a 'Mewtwo' direction of itself with the superpredator Indominus rex.
If this 3rd movie was planned before the Japanese release of Gold & Silver Version (circa 1997/1998), it could potentially had been Nintendo's form of appropriate marketing into the dinosaur lore of the late 1990's happening with The Lost World: Jurassic Park (1997). As that films main premise is about transporting what are now described as valuable living fossils to be made a cultural phenomenon onto the normal human world. It becomes more apparent as a reference when you notice what was intended with this 3rd films original synopsis.
Now having read the link in the description from what it seems, I'm surprised that the first movie was more successful than the second, that is if I read that correctly. Because I find that to be rather absurd.