Probably start by saying:
What are the best rules to use in a nuzlocke?
I think nuzlockes playing on the "set" mode (unable to switch pokes after KO) adds a great level of difficulty that is enjoyable
And then your standard rules of course, and maybe a dupes clause and limit, and a item per battle limit
There are 4 drinks numbered 1 2 3 and 4, only one of them contains water, all others contain poison. How do I find which one doesn't have poison?