My favorite book ever is probably "The Alchemist" by Paulo Coelho. I personally find it very inspiring, but even if I didn't I would be wowed by the original story, great, real characters, and excellent writing.
I loved the first volume of "Akira" but haven't been able to read the other five, I'll have to get on that (even though the movie suuuuuuucked).
"The Amazing Spider-Man" is my favorite comic, Peter Parker is the best superhero of all time as far as I'm concerned, due to his very real ability to connect with the reader. As opposed to say, Superman, who is essentially a god, Batman, who is a billionaire, or Thor, who is actually a god. Peter Parker is just a guy who happens to have superpowers, and he's the origin of every crappy Nick show about a kid balancing his superpowers with his real life.
My least favorite book is "The Mysterious Case of the Dog in the Nighttime." God I hated that book.