In Pokémon X and Y, after being defeated by the player, Preschooler Mia on Route 4 says "Hey! Hey! Listen!" before battle, referencing Navi from The Legend of Zelda series.
In Pokémon X and Y, an NPC in Lumiose City mentions the play Beauty and the Beast, with the titular Beast as a Pokémon.
In Pokémon X and Y, after being defeated by the player, Psychic Robert on Route 10 references the famous "over 9000" meme spawned from Dragon Ball Z, commenting "Wow. You and your Pokémon's power levels are amazing! They're over 9000 for sure!"
In Pokémon X and Y, a Team Flare Grunt found at the Poké Ball Factory says "Don't worry, be happy!", referring to Bobby McFerrin's song Don't Worry, Be Happy.
In Pokémon X and Y, while the ultimate weapon is present in Geosenge Town, a Team Flare Grunt in front of a house in the west of the town comments "Only Team Flare's stayin' alive, stayin' alive.", referencing the Bee Gees song Stayin' Alive.
In Pokémon X and Y, Veteran Timeo in Victory Road will say "my body is ready" before battling the player, a reference to the meme spawned from a statement made by Nintendo of America's President and COO Reggie Fils-Aime at the unveiling of the Wii Balance Board at E3 2007, "My body… my body is ready!"
In Pokémon X and Y, after being defeated by the player, Wikstrom will say "My will, which even shakes spears, trembles at so fine a battle as this!", referencing William Shakespeare.
In Pokémon X and Y, when playing the game in French, Swimmer Romy in Azure Bay sings a variation to R. Kelly's "I Believe I Can Fly" before the player battles her.
In Pokémon X and Y, in the Battle Maison, Waitress Catla makes reference to the lolcatz brand of memes with "Meow, meow, I can haz battle, meow? (Ugh, I really sound like a fool, don't I?)" before battle and "Meowww... I haz lost, meowww. (This job is sooo embarrassing.)" after being defeated.
In Pokémon X and Y, in the Battle Maison, Roller Skater Clio makes reference to So You Think You Can Dance?, saying "Man, I'm so speedy and smooth! I should be on So You Think You Can Skate!" after being defeated.
In Pokémon X and Y, the final chapter of The Looker Detective Agency is named "Here's lookin' at you, kid", a reference to Humphrey Bogart's quote in Casablanca.