What's going to happen is that they're going to play the "Jacob and Eesaw (sp?)" card—those two brothers from the Torah who started feuding—and say that, all of this time, the show was about faith, and god, and hope, and believing, and whatever produces an adequate smoke screen.
Because in reality, the Locke guy is actually speaking the truth; he represents all of our perfectly justified frustrations with the show and the writers who have lead us on, dropped us off, mislead, and not given us one reason to think that this Island and all of the hardship these people have gone through is worth one single thing.
(I've watched Lost from the very beginning. They were doing so well with the monster in the trees, the giant flying bird, the polar bear... Never explained. But any explanation at this point is just an afterthought of the writers).