Well, first off, I love Mew and Rhypherior, because Mew is really cute and Rhypherior is really tough. So let's talk:
1)Pokemon
2)T/S/S
3)Energy
1) Ok, your Pokemon line looks pretty solid, but there are a few tthings that could be changed. Machamp SF and Relicanth SV aren't really needed, they belong in other decks, and the only thing you should be Seeing Off is Rhypherior. They do work as good techs, but with Mew's petty HP, it is hard to set-up, especially because they need energy, plus the energy needed to See Off. Giratina and Dialga too, they shouldn't be in here, considering they need energy plus the See Off. All in all, the Pokemon line should look like this:
4 Mew Prime
2 Rhypherior LV.X
2-1 Uxie X
1 Azelf
I took out Mesprit and Smeargle for separate reasons. First, Smeargle has to be active to Portrait, and the fact that Mew Prime should be your starter doesn't give Smeargle much props. And for Mesprit, this deck is extremely speedy, you won't need one to be easy Chomp snipe bait, as Mew will be filling up your bench anyway.
2)The T/S/S line looks great, but consider the following:
-1 Collector
Maxing these out may help you, but it is dead draw late game.
-3 Pokemon Rescue
Flower Shop and/or Palmer's works better.
+2 Bebe's Search
If a Rhypherior is in your hand and the other in prizes(unlikely, though), it will be very difficult for you to win. Bebe's puts Rhypherior in the deck, and you can get an Uxie to get a good hand again.
+1 FSL or Palmer's
This will help for energy recovery and would wok better than P. Rescue.
+1 PONT
Good hand-refresh. That's about it.
Now this is the part of the deck where I DON'T want you to take all of these ideas, because what is a deck rather than a decklist given to someone who doesn't know the value of each card? I'm not saying this is you.
3) The energy doesn't need much. Take out all of the fighting, 1 Rescue, 1 Call, 1 Warp, and 2 Psychic. That should do the trick.
Now you have 12 free spots, and now you get to decide. I usually use this option to let you play it your way. You can add Mesprit, another tech(I HIGHLY RECOMMEND SNOWPOINT TEMPLE), or some more energy.
I hope I helped.