Focus Sash activates only if the Pokemon that it's attached to has full HP. A Pokemon with Omega Barrage can attack twice, but each attack resolves on its own when considering any effects, such as Focus Sash. Therefore, if the first attack would resolve, doing whatever damage it would do after weakness, resistance (not the case for Yoga Kick, but applies for other attacks unless specified of course), and any effects that might increase or reduce damage. At this point the Pokemon is no longer at full HP, and therefore Focus Sash would not by triggered by the second attack. Focus Sash only triggers if the Pokemon it's attached to has full HP and would be KOed from a single attack, and not anything else, including two Omega Barrage attacks, poison, Abilities, etc.