If financial incentives don't count, then almost everything is "artificial" by your definition.I guess its lucky I've never made anything worth eternalizing
The main difference between tcgs and other regulated markets is that tcg companies have production monopoly and thus their markets have an imposed scarcity. There's no practical situation that stops a reprint of base set for example. There are plenty of financial benefits to not doing so, both for the company and other off-exchange market participants. This is not "natural" supply and demand.
Also, a reprint of base set wouldn't be considered the same as the original.