- Shedinja is the only Pokémon to have a lower base stat total than its pre-evolution.
- Shedinja has the lowest base stat total of any fully evolved Pokémon.
- Shedinja inherits the same personality value, IVs, EVs, OT and ID number as the Nincada that shed it. Among other things, due to retaining personality value, if the Nincada was Shiny, Shedinja will be Shiny as well.
- Shedinja is the only genderless Pokémon that can learn moves through breeding.
- If the Nincada that a Shedinja evolved from has Pokérus, the Shedinja will have it as well.
- Shedinja is the only Pokémon to have a stat not calculated by the standard formula. If it were, Shedinja would have at least 11 HP, even at level 1 with an HP IV of 0 and no HP EVs.
- Despite Shedinja being able to learn Substitute and Rest, they will always fail. However, Shedinja can receive another Pokémon's substitute through Baton Pass.
- Shedinja's Defense and Special Defense stats have no purpose in battle, as any damage will invariably cause Shedinja to faint.
- If a Shedinja were to use Pain Split, it would cut the target's HP in half, similarly to Super Fang.
- If a Shedinja were to use Endeavor, it would always reduce the opponent's HP to 1.