In Red and Blue I used it on Mewtwo.
In Ruby I used it to catch Groudon.
In Diamond I used it to catch Dialga.I was affraid that it was going to faint because it was burned and the HP was very low so I threw it.But in Platinum I didnt used it I caught Giratina with Dusk Ball ,Dialga and Palkia with Ultra Balls and the roaming ones;Mesprit,Articuno,Moltres,Zapdos,Cresselia ,after paralyzing and lowing their health I caught them with Velox Balls.